https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Integrins are double-edged swords in pulmonary infectious diseases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52738 Wed 25 Oct 2023 08:40:27 AEDT ]]> CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32970 in vitro, ex vivo, and in vivo. Results The number of CD151⁺ ASM cells is significantly greater in patients with moderate asthma compared with those in healthy nonasthmatic subjects. From loss- and gain-of-function studies, we reveal that CD151 is required for and enhances G protein-coupled receptor (GPCR)-induced peak intracellular calcium release, the primary determinant of excitation-contraction coupling. We show that the localization of CD151 can also be perinuclear/cytoplasmic and offer an explanation for a novel functional role for CD151 in supporting protein kinase C (PKC) translocation to the cell membrane in GPCR-mediated ASM contraction at this site. Importantly, CD151-/- mice are refractory to airway hyperreactivity in response to allergen challenge. Conclusions We identify a role for CD151 in human ASM contraction. We implicate CD151 as a determinant of AHR in vivo, likely through regulation of GPCR-induced calcium and PKC signaling. These observations have significant implications in understanding the mechanism for AHR and the efficacy of new and emerging therapeutics.]]> Wed 17 Nov 2021 16:31:54 AEDT ]]> The ανβ6 integrin regulates its own expression with cell crowding: implications for tumour progression https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1087 Sat 24 Mar 2018 08:32:10 AEDT ]]> Characterization of mice lacking the tetraspanin superfamily member CD151 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1881 Sat 24 Mar 2018 08:31:18 AEDT ]]> Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the β6 integrin subunit https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1511 Sat 24 Mar 2018 08:30:26 AEDT ]]> Differential expression of pyloric atresia in junctional epidermolysis bullosa with ITGB4 mutations suggests that pyloric atresia is due to factors other than the mutations and not predictive of a poor outcome: three novel mutations and a review of the literature https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4993 A/3111-1G>A. Two cases had no gastrointestinal symptoms or signs of PA. PA is an inconstant feature of the subtype of epidermolysis bullosa known as JEB-PA. It is most likely that multiple factors influence the development of PA and its presence is not predictive of a poor outcome. It is possible that institutions that do not routinely screen immunofluorescence mapping for integrin α6β4 staining in the absence of PA are missing this form of epidermolysis bullosa.]]> Sat 24 Mar 2018 07:44:15 AEDT ]]> Hypoxia and integrin-mediated epithelial restitution during mucosal inflammation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13808 Mon 08 Apr 2019 14:44:23 AEST ]]> Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49107 Fri 05 May 2023 11:32:08 AEST ]]>